EFFECTS OF MULBERRY LEAF ON DIABETES TYPE – 2

 

Introduction - 

Diabetes Meletus, especial

ly type 2 is a fast rising and have become a global epidemic. Treating it in a natural way an Eminent herbal extract – Mulberry (Morus, A Genus of flowering plants in the family Morceau) leaf has been used because of its Hypoglycemic effects.

 

Diabetes mellitus is a disease that affects the body's regulation of blood glucose, the main symptom of which includes thirst, frequent urination, hunger and weight loss.

As for Medicinal terminology certain traditional plants have been used and these herbs have been shown to have been beneficial over western medication in treating Diabetes. 

 

Discovery -

This herbal medication was first discovered by china and resided by in DIVINE HUSBAND- Man's classic of Materia Medica and later with wider use and properties of Mulberry leaf it was recorded in comprehensive outline of Materia Medica – An extensive summary of Chinese herbal pharmacology.

Then the letter usage of this leaf was developed in form of brewed teas by Chinese.

 

Pharmacology - 

This Mulberry leaf with hypo-glycemic effects include

•       Alkaloids

•       Flavonoids

•       Polysaccharide

•       Amino acids

•       Simple phenyl propanoid

•       Phenols   

 

Mechanism of Anti-Diabetes effect of mulberry leaf

Alkaloids - The Mulberry alkaloids especially 1-deoxy

Nojirimycin (DNJ), decrease α- glucosidase activity by competitive inhibition through binding to every active site and mimic natural substance.    

Oral administration of 0.24% DNJ and its derivative was found to inhibit absorption of sucrose and polysaccharides in human.

 

Flavonoids - It effects on α-glucosidase activity and can suppress blood glucose level. Two flavonoids (iso quercitrin and astragalin) are to inhibit  α-glucosidase.

 

Polysaccharides -

Polysaccharides from mulberry leaf have been shown to decrease blood glucose level, improve glucose tolerance, and increase the hepatic glycogen content, thus regulating glucose metabolism in diabetic mice and promoting insulin secretion in normal rats. Polysaccharides from mulberry leaf have also been found to inhibit α-glucosidase activity The highly-purified polysaccharides αarabinose, α-xylose, α-glucose, α-rhamnose, and α-mannose that were extracted from mulberry leaf were able to induce regeneration of pancreatic β-cells, which were then able to effectively secreted insulin and reduce liver fat accumulation in diabetic rats. Glycosides and their aglycons that were isolated from a water extract of mulberry leaf were found to have potential type 2 antidiabetic activity.

 While the inhibition of α-glucosidase plays a crucial role in the antidiabetes effect of mulberry leaf, an individual compound cannot elucidate metabolic mechanisms, thus molecular mechanisms need investigating

 

Extraction -

The process involves different type like Brewing time, Concentration of organic solution, Extraction solution temperature, Water extracts and Ethanolic extracts.

 

Benefits -

As the Mulberry leaves are highly nutritious, they are used to

•       Lower blood sugar and insulin

•       Improve heart health by reducing cholesterol  

•       Prevent atherosclerosis

•       Promote liver health  

•       Weight loss

•       Anti-cancer effects

 

Precautions -

•       Dizziness

•       Bloating

•       Nausea

And if these adversity increases consulting a physician is required.

 

 

            

                              Done by – Archana Gulia
                                                             B Pharmacy
                                       RAGHU COLLEGE OF PHARMACY
                                        ID –CSRPL_INT_WKD_VIZ_0027/20.